Councillors representing people living near the A38 in Plymouth are calling for the speed limit to be reduced.
They say they are worried about the number of collisions, congestion and pollution on the stretch of the Parkway.
Labour Cabinet member for roads Mark Coker said the council was already working closely with Highways England to minimise the risk of incidents.
A spokesperson for the Government agency said the safety record of the A38 was actively monitored to identify areas for improvements.
Read PlymouthLive’s opinion piece on the case for making the A38 a 50mph zone here.
Peverell councillor Tony Carson called for the 70mph limit to be cut to 50mph “to improve road safety”.
Cllr Ian Bowyer in Eggbuckland said the recent closure of Forder Valley Road West meant more congestion as vehicles were directed towards the Manadon roundabout.
He said: “At the very least, speed on the A38 should be reduced as a temporary measure.”
Councillors have also raised concerns about noise levels and air pollution from traffic on the route.
The Conservatives called on the city council to start discussions with Highways England about reducing the speed limit.
Councillor Mark Coker, Plymouth City Council’s Cabinet Member for Strategic Planning and Infrastructure, said: “Every single collision on Plymouth’s roads is of great concern to the Council. “
The Labour councillor said: “This is about lives that are potentially changed or lost – not just statistics.
“The A38 is part of the network owned and operated by Highways England but we work closely with them and the Peninsula Road Safety Partnership to minimise the risk of road injuries and fatalities in the city.
“I’d be happy for any ward councillors to contact me or our highways team to discuss their concerns about road safety in their area.”
Marcus Anning, Highways England’s South West Asset Needs Manager, said: “The safety records of all Highways England roads, including the A38, are actively monitored to identify areas where safety improvements can be made.
“We work closely with our local authority partners, as part of the Peninsula Road Safety Partnership, to identify any interventions required and to ensure our roads in Devon and Cornwall are as safe as they can be.”
Earlier this month, the 17-month closure of the western section of Forder Valley Link Road was brought into force as part of work on the congestion-busting Forder Valley Link Road.
As reported, work started in 2019 on the three-year project to build the £49million 1-kilometre (0.62-mile) new road including a bridge over the Bircham Valley linking the junction of Novorossiysk Road and Forder Valley Road to William Prance Road at Derriford.
It will create a new route from the A38 to the north of the city, reducing journey times to key sites including Derriford Hospital and unlocking land for development where more than 4,000 homes are planned over the next 15 years.
Read more about all of the traffic restrictions in place here.