Plymouth Argyle midfielder Lewis Macleod is expected to be out of action for a further three to four weeks, according to Ryan Lowe.
Macleod has already missed four matches due to a knee injury which saw him substituted in the first half of the 1-1 draw with Shrewsbury Town at Home Park on September 26.
The 26-year-old has had one injection in the knee, with another two planned, which it is hoped will resolve the issue.
It will take a little time, though, which means that Macleod will not be able to play against his former club, Wigan Athletic, at the DW Stadium on Saturday.
Before that, the Pilgrims have a League One game against third-placed Lincoln City at Sincil Bank on Tuesday night.
Lowe said: “Lewis has had an injection in his knee, which should help. He has got two further injections, which will certainly help him along the way.
“We are hoping to have him back in maybe three weeks or so.
“We got it looked at again, we got another specialist opinion on it, and he has decided that we need to take him out the picture a little bit and get him right.
“Lewis is trying to get through this little pain barrier, and we don’t want that. He will be missing for, I would say, three to four weeks.”
The absence of Macleod has been compensated for by the signing of Tyrese Fornah on loan from Nottingham Forest.
Fornah has taken over the defensive midfield role which Macleod had been playing in before he was sidelined.
Striker Ryan Hardie missed Argyle’s 2-1 victory over Northampton Town at Home Park on Saturday after a spell in self-isolation after a positive COVID-19 test.
Hardie is expected to be part of the Pilgrims’ squad which travels to Lincoln, though.
With games still being played behind closed doors due to the coronavirus pandemic, the kick-off at Sincil Bank has been brought by 45 minutes to 7pm.
The Argyle squad will still not return to Plymouth until the early hours of Wednesday.
But as they will be back not quite as late it should allow for better preparation for the game against Wigan.
Lowe said: “We thank Lincoln for that. We asked them for a little bit earlier in all honesty because there are no fans.
“It’s 45 minutes better for our lads. We have to make sure after the Lincoln game that it’s done right.
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“We have to recover straight away and get the lads fed, and sleep, and everything else that goes into it, ready for another important game on Saturday.
“So it’s definitely worth it’s weight in gold a seven o’clock kick-off.”