Plymouth Argyle will be without five-goal top scorer Luke Jephcott for their Sky-televised League One game against Portsmouth on Monday, November 16.
It follows his call-up to the Wales under-21 international for two European Championship qualifiers in the next window for international fixtures.
Jephcott will also be absent when Argyle play Newport County at Home Park next Tuesday in their third and final EFL Trophy group game.
It is unlikely that Jephcott would have featured in that match anyway, but it is a blow for the Pilgrims that he will miss the visit of Portsmouth.
Aberystwyth-born Jephcott made his Wales under-21s debut as a substitute when they lost 1-0 away to Bosnia and Herzegovina in Zenica at the start of September.
He then missed their 5-0 defeat away to Belgium last month after a spell out of the Argyle side due to a thigh injury.
Jephcott has now been recalled by Wales under-21s coach Paul Bodin for their final two Group 9 qualifying games, the first of which is against Moldova at the Raceourse Ground, Wrexham, on Friday, November 13.
That will be followed by an away game against Germany in Braunshweig on Tuesday, November 17.
Jephcott will then be available for Argyle’s League One trip to Fleetwood Town at the weekend.
Wales cannot qualify for the 2021 European Championship finals as they are bottom of Group 9 with a record of two wins and four defeats from their six matches.
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Germany can guarantee their qualification, ahead of Belgium, by beating Wales on November 17.
Argyle manager Ryan Lowe will still have plenty of attacking options while Jephcott is away on international duty, with Ryan Hardie, Frank Nouble, Dom Telford and Timmy Abraham all available to him.